Treatment details

Hyaluronic Acid

What is the difference between cross-linked and non-cross-linked hyaluronic acid, which is used and why?

Through cross-linking, a three-dimensional network of D-glucuronic-N-acetylglucosamine dimer chains is formed, making the substance more rigid and stable, so that it lasts longer in the dermal tissue where it is injected. Therefore, with little cross-linking, the hyaluronic acid will be more fluid and volatile, while the greater the cross-linking, the greater the density and durability. Non-cross-linked hyaluronic acid, on the other hand, will last very little, as it degrades more easily, its density and durability is much lower and it is much more vulnerable to attack by hyaluronidase (the enzyme that degrades it). In aesthetics, both are used, the non-crosslinked one alone or associated with vitamins or amino acids to nourish the skin and the cross-linked one to fill wrinkles or furrows, to hold structures that give way (“lifting without surgery” effect) or to project lost planes (volume increase).